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  • Title: [Synthesis and antibacterial activities of 3,6-disubstituted-5,6-dihydrogen-1,2,4-s-triazolo-[3,4-b]-1,3,4-thiadiazoles].
    Author: Shi HJ, Wang ZY, Shi HX.
    Journal: Yao Xue Xue Bao; 2001 Apr; 36(4):310-2. PubMed ID: 12580064.
    Abstract:
    AIM: To synthesize a series of new fused heterocyclic compounds containing 1,2,4-triazole and 1,3,4-thiadiazole rings. METHODS AND RESULTS: Nine new fused heterocyclic compounds have been synthesized by the reaction of 3-p-nitrophenoxymethyl-4-amino-5-mercapto-1, 2, 4-triazole with aromatic aldehydes in the presence of acid. The reaction conditions for the synthesis have been investigated. The structures of the synthesized compounds were confirmed by elemental analysis, IR, 1HNMR and MS. All of the compounds were screened for their biological activities. CONCLUSION: The results show that some compounds (2c, 2d, 2e, 2f) showed strong antibacterial activities.
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