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  • Title: Radioprotective effectiveness and toxicity of ATP, AET and serotonin applied individually or simultaneously to mice. II. Dose depending protection by single agents.
    Author: Benova D.
    Journal: Strahlentherapie; 1976 Mar; 151(3):274-7. PubMed ID: 1258098.
    Abstract:
    The work reported was done as a part of a detailed study on the antiradiation effects of three chemical agents-ATP, AET and serotonin-given individually or simultaneously, the ultimate aim being the identification of an optimally effective and non-toxic dose ratio for the triple combination of protectants. Individual PD50 (protectant dose ensuring 50% survival after lethal irradiation) values were found to be 166 mg/kg and 37 mg/kg for AET and serotonin, respectively. ATP was most effective (45% of 30-day-survival) at 1200 mg/kg in face of a level of X-irradiation above the minimum lethal dose. Some sex differences were observed in protection provided by everyone of the three agents, females being more susceptible to the protective action.
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