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  • Title: [Effects of UV-radiation of different spectral composition on content of sterols in rat skin].
    Author: Datsenko ZM, Semenov VL, Bendt VP.
    Journal: Ukr Biokhim Zh; 1976; 48(1):86-8. PubMed ID: 1258165.
    Abstract:
    When irradiating rats with sources of UV-radiation of different spectral composition a decrease in a relative content of cholesterol is found in the animal skin. Simultaneously an increase in the content of such cholestorol biosynthesis precursors as lathosterol and 7-dehydrocholesterol is observed. The formation of cholesterol photooxidation products under the effect of UV-radiation in vivo is shown. The quantitative ratios of sterols under study depend on spectral characteristics of the applied UV-radiation sources. The cholesterol photooxidation products and antirachitic compounds formed in skin under the effect of UV-radiation are supposed to take part in inhibition of cholesterol biosynthesis.
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