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  • Title: Magnetic resonance of the breast: correlation between enhancement patterns and microvessel density in malignant tumors.
    Author: Carriero A, Ambrossini R, Mattei PA, Angelucci D, Bonomo L.
    Journal: J Exp Clin Cancer Res; 2002 Sep; 21(3 Suppl):83-7. PubMed ID: 12585660.
    Abstract:
    The continuous growth of a solid tumor is contingent upon the induction and formation of new vascular structures (angiogenesis). Several studies have established a close correlation between the microvessel density (MVD) of a tumor and its growth capacity. Therefore, a non-invasive method to accurately assess tumor MVD in vivo would be clinically useful. We studied 20 consecutive patients (age range: from 39 to 78 yrs; average age: 58.9 yrs), with malignant breast neoplasms using dynamic MR examinations with a paramagnetic contrast agent and post-operative pathological evaluation. We found that the differences in dynamic MRI enhancement are a direct consequence of microvascular distribution within the neoplasm. This study did not yield a statistically significant correlation between high microcirculation neo-formation and high aggressiveness of the neoplasm, but did indicate that further studies with a larger study populations are necessary.
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