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  • Title: The crystal structure of a plant lectin in complex with the Tn antigen.
    Author: Babino A, Tello D, Rojas A, Bay S, Osinaga E, Alzari PM.
    Journal: FEBS Lett; 2003 Feb 11; 536(1-3):106-10. PubMed ID: 12586347.
    Abstract:
    The structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution. The N-acetylgalactoside moiety of the ligand binds to the primary combining site of VVLB4 in a similar way as observed for other Gal/GalNAc-specific plant lectins. The amino acid moiety of the Tn antigen is largely exposed to the solvent and makes few contacts with the protein. The structure of the complex provides a framework to understand the differences in the strength of VVLB4 binding to different sugars and emphasizes the role of a single protein residue, Tyr127, as a structural determinant of Tn-binding specificity.
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