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  • Title: [Immunohistochemical flow chart to differentiate between primary adenocarcinoma and the most frequent extragynecological metastases in the ovary].
    Author: Pires Y, Andrade L, Cuello M, Chuaqui R.
    Journal: Rev Med Chil; 2002 Nov; 130(11):1232-40. PubMed ID: 12587505.
    Abstract:
    BACKGROUND: The pathological differential diagnosis between primary and metastatic ovarian malignant tumors is usually difficult, specially for tumors originating in the gastrointestinal system or breast. AIM: To define an immunohistochemical flow chart to discriminate these tumor types. MATERIAL AND METHODS: We performed a immunostaining analysis using a panel of six antibodies (CK 7, CA 125, CEA, CK20, BRST-2 and CA 15-3) in 3 tumor groups: 11 ovarian, 14 breast and 12 colonic primary tumors and in a study group of 38 ovarian tumors whose primary origin was unknown. RESULTS: We defined an ovarian immunohistochemical pattern (CEA-/CK20-, 45% in ovarian tumors, 0% in breast or colonic tumors, p < 0.001); an ovary/breast pattern (CEA+/CK20-, 0% in colonic tumors, p < 0.001): a breast pattern (CEA+/CK20-/BKST-2+, 64% in breast tumors and 0% in colonic and ovarian tumors, p < 0.001) and a colonic pattern (CEA+/CK20+/CK7-, 67% in colonic tumors and 0% in breast and ovarian tumors, p < 0.001). CONCLUSIONS: Employing a simple panel of antibodies, characteristic immunohistochemical patterns were defined for ovarian, breast and colonic tumors. These patterns allowed the identification of the origin of most tumors of the study group.
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