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  • Title: Coffee increases state anxiety in males but not in females.
    Author: Botella P, Parra A.
    Journal: Hum Psychopharmacol; 2003 Mar; 18(2):141-3. PubMed ID: 12590408.
    Abstract:
    Coffee, reproducing the conditions under which caffeine is normally ingested, containing 3, 75, 150 or 300 mg of caffeine was given to healthy male and female volunteers. 25-30 min after drinking the beverage, they completed the Spanish version of the state-trait anxiety inventory (STAI). The beverage increased state anxiety, in a dose-dependent manner, in males but not in females. This could be due to a lesser sensitivity of females to coffee.
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