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  • Title: Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.
    Author: Kakeya H, Takahashi-Ando N, Kimura M, Onose R, Yamaguchi I, Osada H.
    Journal: Biosci Biotechnol Biochem; 2002 Dec; 66(12):2723-6. PubMed ID: 12596876.
    Abstract:
    Zearalenones are mycotoxins with estrogenic activity consisting of a resorcinol moiety fused to a 14-membered macrocyclic lactone and are produced by various Fusarium species. We found that Clonostachys rosea IFO 7063 was effectively capable of converting zearalenone (1) to cleavage product (2), 1-(3,5-dihydroxyphenyl)-10'-hydroxy-1'E-undecene-6'-one. Moreover, cleavage product 2 did not show potent estrogenic activity like that of 1 and 17beta-estradiol in the human breast cancer MCF-7 cell proliferation assay.
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