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  • Title: Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice.
    Author: Steidl JV, Gomez-Isla T, Mariash A, Ashe KH, Boland LM.
    Journal: Neuroreport; 2003 Feb 10; 14(2):219-23. PubMed ID: 12598733.
    Abstract:
    Hippocampal synaptic plasticity was studied in transgenic mice over-expressing human alpha-synuclein containing the A30P Parkinson's disease mutation. Medial perforant path-dentate granule cell synapses showed enhanced paired-pulse depression (PPD) for short interpulse intervals (< 200 ms), without differences in basal transmission. Extracellular calcium reduction failed to rescue the enhanced PPD. Paired-pulse facilitation in the CA1 region was normal in slices from transgenic mice, but enhanced synaptic depression was revealed upon repetitive stimulation of the Schaffer collaterals. Long-term potentiation in the CA1 field was not impaired in slices from transgenic mice. These results suggest that mutant alpha-synuclein accumulation impairs short-term changes in synaptic strength when neurotransmitter availability is limited due to enhanced release probability or repetitive synaptic activity.
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