These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Study on the differentiation of K562 cell-line induced by Tanshinone II A].
    Author: Wu Y, Yang Y, Meng W, Li Y, Jia Y, Liu T.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 2002 Jan; 33(1):80-3. PubMed ID: 12599436.
    Abstract:
    OBJECTIVE: To investigate the effect of Tanshinone II A on K562 cell-line and its possible mechanism. METHODS: Cell culture, cytomorphology and cytometrics were used. RESULTS: The proliferative inhibition of K562 cells induced by Tanshinone II A was dose-independent, and the degrees of erythroid differentiation induced by 30 nmol/L ACM and 0.5 microgram/ml Tanshinone II A were not statistically different (P > 0.05). CONCLUSION: Tanshinone II A has an inhibitive effect on the proliferation of K562 cells and an inductive effect on the differentiation of erythrocyte series. The mechanisms may be related to the changes of cell cycle and gene expressions.
    [Abstract] [Full Text] [Related] [New Search]