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  • Title: [The effects of ethanol on neuromuscular junctions of adult toad].
    Author: Yu J, Lü G, Xu J.
    Journal: Hua Xi Yi Ke Da Xue Xue Bao; 2001 Jun; 32(2):274-6. PubMed ID: 12600106.
    Abstract:
    OBJECTIVE: To investigate the effects of ethanol on the transmission at the neuromuscular junctions(NMJ) and the possible mechanism thereby. METHODS: The effects of ethanol on the endplate potential (EPP) and miniature endplate potential(MEPP) of sciatic nerve-sartorious muscle preparations of 20 adult toads (Bufo bufo gargarizans) were studied in vitro by means of intracellular microelectrode recording. RESULTS: Ethanol could cause the changes in EPP amplitude so as to influence the transmission at NMJ, and the effects apparently depended on the concentration of the ethanol. A proper concentration of ethanol could produce a significant increase in EPP amplitude and therefore facilitate the transmission at the NMJ. A proper concentration of ethanol also could produce a significant increase in MEPP frequency but had no influence on MEPP amplitude. CONCLUSION: Ethanol can increase the quantal number of transmitters released from presynaptic part. That may be one of the reasons why ethanol can facilitate the transmission at the NMJ.
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