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  • Title: [Effects of mitogen-activated protein kinase(MAPK) in cell signal transduction of chronic myelogenous leukemia cell line K562].
    Author: Shang ZC, Sun BZ, Chen ZN, Wang W, Feng Q, Wang S, Zhang T.
    Journal: Ai Zheng; 2003 Feb; 22(2):140-2. PubMed ID: 12600286.
    Abstract:
    BACKGROUND & OBJECTIVE: Ras-MAPK signal transduction has been thought to play an important role in the carcinogenesis of chronic myelogenous leukemia. In this study, the authors investigated the effects and mechanism of mitogen-activated protein kinase (MAPK) in cell signal transduction of chronic myelogenous leukemia(CML). METHODS: After MAPK antisense oligodeoxynucleotide (ASO) was introduced into K562 cell line by liposomal transfection, the effects of ASO on K562 cell were evaluated by cell proliferation, DNA synthesis, MAPK protein content and MAPK activity. RESULTS: The cell proliferation, DNA synthesis, MAPK protein content and MAPK activity were significantly inhibited by MAPK ASO, the inhibitory rates were 51.8%, 57.1%, 45.3%, and 61.6%, respectively,with significant difference in comparison to the control (P<0.05). CONCLUSION: MAPK plays an important role in the signal transduction of CML and MAPK may become a new target in the treatment of CML.
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