These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Derivatization of aminoalkylphosphonic acids for characterization by gas chromatography mass spectrometry.
    Author: Rueppel ML, Suba LA, Marvel JT.
    Journal: Biomed Mass Spectrom; 1976 Feb; 3(1):28-31. PubMed ID: 1260113.
    Abstract:
    A general derivatization method has been developed for both primary and secondary aminoalkyl-phosphonic acids. Derivatization is effected by reaction with trifluoroacetic acid and trifluoroacetic acid anhydride followed by esterification using ethereal diazo-n-butane. This method can be used for microgram quantities and permits ready characterization by both gas chromatography and gas chromatography mass spectrometry. The structure of this derivative has been verified by mass spectrometry and proton magnetic resonance. Fragmentation patterns were confirmed by high resolution mass spectrometry, isotope labeling and the formation of derivative analogs.
    [Abstract] [Full Text] [Related] [New Search]