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  • Title: Nasal bone length throughout gestation: normal ranges based on 3537 fetal ultrasound measurements.
    Author: Sonek JD, McKenna D, Webb D, Croom C, Nicolaides K.
    Journal: Ultrasound Obstet Gynecol; 2003 Feb; 21(2):152-5. PubMed ID: 12601837.
    Abstract:
    OBJECTIVE: To establish normal ranges for nasal bone length measurements throughout gestation and to compare measurements in two subsets of patients of different race (African-American vs. Caucasian) to determine whether a different normal range should be used in these populations. METHOD: Normal nasal bone length reference ranges were generated using prenatal measurements by a standardized technique in 3537 fetuses. RESULTS: The nasal bone lengths were found to correlate positively with advancing gestation (R(2) = 0.77, second-order polynomial). No statistical difference was found between African-American and Caucasian subjects. CONCLUSION: These reference ranges may prove to be useful in prenatal screening and diagnosis of syndromes known to be associated with nasal hypoplasia. Different normal ranges for African-American and Caucasian women are not required.
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