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  • Title: The metabolic clearance rate of dehydroisoandrosterone sulfate. III. The effect of thiazide diuretics in normal and future pre-eclamptic pregnancies.
    Author: Gant NF, Madden JD, Siteri PK, MacDonald PC.
    Journal: Am J Obstet Gynecol; 1975 Sep 15; 123(2):159-63. PubMed ID: 126019.
    Abstract:
    The present study reports that the metabolic clearance rate of dehydroisoandrosterone sulfate (MCRDS) is decreased by thiazide diuretics during normal and future pre-eclamptic pregnancies. This observation supports the thesis that diuretics represent a potential hazard to the fetus by decreasing placental perfusion.
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