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  • Title: Effects of mazindol, a non-phenylethylamine anorexigenic agent, on biogenic amine levels and turnover rate.
    Author: Carruba MO, Groppetti A, Mantegazza P, Vicentini L, Zambotti F.
    Journal: Br J Pharmacol; 1976 Apr; 56(4):431-6. PubMed ID: 1260223.
    Abstract:
    1 Mazindol is a new anorexigenic agent which possesses a different chemical structure from that of phenylethylamines, but shows a pharmacological profile similar to that of (+)-amphetamine. 2 Mazindol neither altered whole brain monoamine levels (noradrenaline (NA), dopamine, 5-hydroxytryptamine (5-HT)) nor changed NA levels in the hypothalamus or dopamine levels in the caudate nucleus. 3 Mazindol enhanced dopamine turnover rate in the caudate nucleus, as shown by the increased rate of dopamine decline after blockade of catecholamine synthesis by alpha-methyl-p-tyrosine and decreased the conversion index of (3H)-tyrosine into brain NA. 4 Mazindol administration did not modify pargyline-induced decline of 5-hydroxyindoleacetic acid suggesting that 5-HT turnover is not altered by this drug.
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