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  • Title: Effects of methanol on the retinal function of juvenile rats.
    Author: Plaziac C, Lachapelle P, Casanova C.
    Journal: Neurotoxicology; 2003 Mar; 24(2):255-60. PubMed ID: 12606297.
    Abstract:
    We have investigated the effect of methanol exposure on the retinal function of juvenile rats. The electroretinogram (ERG) and oscillatory potentials (OPs) were recorded prior to and up to 72 h after the administration of methanol. Data were compared to a control group which was only exposed to physiological saline. Our findings can be summarized as follows: methanol generally reduced the amplitude of all retinal potentials, and in some cases, to baseline levels. The ERG b-wave was affected earlier and more prominently than the a-wave. All measured OPs (2-4) were decreased but OP2 was less affected, suggesting that the cone pathway may be less sensitive to methanol than the rod-mediated pathway. These data indicate that juvenile rats (21 days old, i.e. with an immature synaptic development) present a sensitivity to methanol comparable to that observed in adult animals.
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