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  • Title: Glassy cell carcinoma of the cervix.
    Author: Littman P, Clement PB, Henriksen B, Wang CC, Robboy SJ, Taft PD, Ulfelder H, Scully RE.
    Journal: Cancer; 1976 May; 37(5):2238-46. PubMed ID: 1260713.
    Abstract:
    A clinicopathologic analysis of 13 cases of glassy cell carcinoma of the uterine cervix is presented. The glassy cell carcinoma is considered to be a poorly differentiated mixed adenosquamous carcinoma. Its histologic appearance is distinctive, being characterized by cells with a moderate amount of cytoplasm having a ground glass or finely granular appearance, a distinct cell wall that stains with eosin and PAS, and enlarged nuclei with prominent nucleoli. In the present study this tumor was associated with extrapelvic spread in 6/13 cases at diagnosis. Results were poor with either surgery and/or radiotherapy. Only four of 13 patients survived 5 years. The glassy cell carcinoma appears to be a distinct clinicopathologic entity which warrants a place in the classification of carcinoma of the cervix.
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