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  • Title: Inhibition of tubulin-microtubule polymerization by drugs of the Vinca alkaloid class.
    Author: Owellen RJ, Hartke CA, Dickerson RM, Hains FO.
    Journal: Cancer Res; 1976 Apr; 36(4):1499-502. PubMed ID: 1260766.
    Abstract:
    A series of Vinca alkaloids were found to block polymerization of crude tubulin extracts of porcine brain in a dose-dependent manner. This appears to be a specific effect occurring at low concentrations of drug. The concentration of vinblastine that prevents polymerization by 50% was 4.3 x 10(-7) mole/liter for a tubulin concentration of 3.0 mg/ml, and this concentration is consistent with levels achieved in vivo following routine pharmacological doses in humans.
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