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  • Title: [Humoral immune response to the retinal S-antigen in premature infants and its role in the development and course of retinopathy of prematurity].
    Author: Katargina LA, Slepova OS, Skripets PP, Dement'eva GM, Chernonog IN, Kalamkarov GR.
    Journal: Vestn Oftalmol; 2003; 119(1):20-2. PubMed ID: 12608038.
    Abstract:
    The humoral immune response to the retinal S-antigen was studied in premature babies with active and cicatricle stages of retinopathy of the premature (RP) and in the controls (102 serum test). The presence of antibodies to the S-antigen of classes IgG and IgM was established by the enzyme multiplied analysis and by an authors' developed test-system. A definite specific humoral response to the S-antigen correlated with the nature of the course and prognosis of the disease was found in 71% of cases. The first peak of IgM-antibodies was found in babies of the risk-group (preretinopathy), it correlated with a poor prognosis (progression of RP). The second peak was highly pronounced in babies with the terminal cicatricle stages of RP. The wave-like dynamics of IgG-antibodies suggests that specific circulating immune complexes shape up. The role of immune responses, induced by the retinal S-antigen, in the RP pathogenesis is discussed.
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