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  • Title: Bistratamides E-J, modified cyclic hexapeptides from the Philippines ascidian Lissoclinum bistratum.
    Author: Perez LJ, Faulkner DJ.
    Journal: J Nat Prod; 2003 Feb; 66(2):247-50. PubMed ID: 12608858.
    Abstract:
    The Philippines ascidian Lissoclinum bistratum contained the known metabolites bistratamides C and D, together with six novel modified cyclic hexapeptides, bistratamides E-J. The structures of bistratamides E-J were elucidated by interpretation of spectral data, and the absolute stereochemistry of the constituent amino acids was determined after ozonolysis and acid-catalyzed hydrolysis. Bistratamides E-J were moderately cytotoxic in the HCT-116 cell line assay.
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