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  • Title: The relationship between the turnover of UTP and RNA synthesis in cultured cells treated with aflatoxin B1.
    Author: Clifford JI, Garvican L, Rees KR.
    Journal: Chem Biol Interact; 1976 May; 13(2):165-71. PubMed ID: 1260951.
    Abstract:
    Methods have been adapted to measure the specific activity of UTP in cells in monolayer culture. In HeLa cells labelled with [3H]uridine and treated with aflatoxin B1 there was reduced radioactivity in crude acid extracts, but the toxin did not affect the radioactive incorporation into UTP. Using cells in which the UTP was pre-labelled, the subsequent addition of aflatoxin B1 inhibited UTP incorporation into RNA. Accordingly aflatoxin B1 did not inhibit the uptake of uridine or the latter's conversion to UTP but inhibited the incorporation of UTP into RNA.
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