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  • Title: Evolutionary medicine: from dwarf model systems to healthy centenarians?
    Author: Longo VD, Finch CE.
    Journal: Science; 2003 Feb 28; 299(5611):1342-6. PubMed ID: 12610293.
    Abstract:
    Restriction of the number of calories consumed extends longevity in many organisms. In rodents, caloric restriction decreases the levels of plasma glucose and insulin-like growth factor I (IGF-1) and postpones or attenuates cancer, immunosenescence, and inflammation without irreversible side effects. In organisms ranging from yeast to mice, mutations in glucose or IGF-I-like signaling pathways extend life-span but also cause glycogen or fat accumulation and dwarfism. This information suggests a new category of drugs that could prevent or postpone diseases of aging with few adverse effects.
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