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  • Title: Defective erythrocyte pyruvate kinase.
    Author: Staal GE, Ceerdink RP, Vlug AM, Hamelink ML.
    Journal: Clin Chim Acta; 1976 Apr 01; 68(1):11-5. PubMed ID: 1261049.
    Abstract:
    A defective pyruvate kinase (EC 2.7.1.40) is described. The abnormal PK is characterized by a shift in the R in equilibrium T equilibrium to the T-state. The Ko.5 for the substrate phosphoenol pyruvate is about 6 times higher than for the normal enzyme, while the KM value for the positive effector Fru-1, 6-P2 is increased. In agreement with a shift to the T-state is the increased affinity of the abnormal enzyme for the negative effectors ATP and alanine. The results are discussed in relation to other abnormal pyruvate kinases.
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