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  • Title: Lack of association between -384 and 114 IL-2 gene polymorphisms and rheumatoid arthritis.
    Author: Fedetz M, Matesanz F, Cáliz R, Ferrer MA, Collado MD, Alcina A, Martín J.
    Journal: J Rheumatol; 2003 Mar; 30(3):435-7. PubMed ID: 12610796.
    Abstract:
    OBJECTIVE: To investigate the association of 2 single nucleotide polymorphisms (SNP) at positions -384 and 114 in the human interleukin 2 (IL-2) gene with susceptibility to and severity of rheumatoid arthritis (RA). METHODS: Genotyping for these IL-2 variants was performed by a polymerase chain reaction restriction fragment length polymorphism method in 174 RA patients and 153 control individuals. RESULTS: No statistically significant differences were observed when the -384 and 114 IL-2 genotype distributions between RA patients and healthy controls were compared. In addition, no association was found between the IL-2 genotypes with any demographic and clinical variables tested. CONCLUSION: Our results provide no evidence for genetic association conferred by the -384 and 114 IL-2 SNP with respect to susceptibility and severity of RA.
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