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  • Title: [Relationship of immune imbalance with the development of multiple organ failure in patients with complicated postoperative period after the cardiac surgery].
    Author: Onishchenko NA, Maremshanov AM, Suskov OI, Tsypin AB, Rebrova OIu.
    Journal: Anesteziol Reanimatol; 2002; (6):45-8. PubMed ID: 12611157.
    Abstract:
    A relationship of the functional status of the viscera with the immune system was studied in 38 cardiac surgical patients with septic complications and multi-organ failure in the postoperative period. In deceased patients (n = 13), the total functional organ compensation index was lower whereas the total functional decompensation index was higher than those in survivors (n = 25). In the deceased patients, each vital organ was more commonly decompensated than that in the survivors, but a definite discrepancy was ascertained only in the immune system (92% versus 16%, p < 0.0001). The average number of decompensated organs was found to increase with the severity of immunological disorders. Therefore, there is a rather high correlation between the functional status of vital organs and the degree of immunological imbalance. The authors show it necessary to use immunity-corrective drugs (splenopid) to enhance the efficiency of treatment organ failure.
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