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  • Title: Steroid metabolism of foetal tissues. I. Metabolism of pregnenolone-4-14C by human foetal ovaries.
    Author: Schindler AE, Friedrich E.
    Journal: Endokrinologie; 1975 Feb; 65(1):72-9. PubMed ID: 126147.
    Abstract:
    The metabolism of pregnenolone-4-14C of ovaries from human foetuses ranging in age from the 14th through the 42th week of gestation was studied by a double isotope method in vitro. Progesterone was found as the main metabolite. The rate of conversion is correlated with histochemical findings of the same material and comparison with the FSH- and LH-concentration in human foetal pituitaries is made. As further metabolites only 17alpha-hydroxypregnenolone and dehydroepiandrosterone were isolated. For comparison tissue from a polycystic ovary was investigated with the same method.
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