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  • Title: Catabolism of cholesterol by bovine adrenal-cortex enzymes: in vitro formation of oxygenated sterols and side-chain cleavage products.
    Author: Bosisio E, Galli G, Nicosia S, Galli Kienle M.
    Journal: Eur J Biochem; 1976 Apr 01; 63(2):491-7. PubMed ID: 1261558.
    Abstract:
    The identification of sterols and steroids formed by incubation of [7alph-3H, 26-14C]cholesterol with mitochondrial enzymes from bovine adrenal cortex is reported. Only 17% of the radioactivity associated with cholesterol metabolites was found in pregnenolone, whereas 15% was reliable to oxygenated sterols and 6% to steroid compounds. The significance of the formation of these compounds is discussed particularly as regards oxygenated cholesterol derivatives.
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