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  • Title: Platelet activation and the formation of the platelet plug: deficiency of ADAMTS13 causes thrombotic thrombocytopenic purpura.
    Author: Tsai HM.
    Journal: Arterioscler Thromb Vasc Biol; 2003 Mar 01; 23(3):388-96. PubMed ID: 12615692.
    Abstract:
    In the circulation, a plasma metalloprotease, ADAMTS13, cleaves von Willebrand factor (vWF) in a shear-dependent manner. This article reviews the role of this cleavage in regulating vWF-platelet interaction and proposes a scheme for understanding how a deficiency of ADAMTS13 results in the development of microthrombi in patients with thrombotic thrombocytopenic purpura.
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