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  • Title: YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.
    Author: Nagai K, Kamigiri K, Matsumoto H, Kawano Y, Yamaoka M, Shimoi H, Watanabe M, Suzuki K.
    Journal: J Antibiot (Tokyo); 2002 Dec; 55(12):1036-41. PubMed ID: 12617512.
    Abstract:
    A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells.
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