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  • Title: Selegiline in the treatment of Parkinson's disease: its impact on orthostatic hypotension.
    Author: Bhattacharya KF, Nouri S, Olanow CW, Yahr MD, Kaufmann H.
    Journal: Parkinsonism Relat Disord; 2003 Mar; 9(4):221-4. PubMed ID: 12618057.
    Abstract:
    Less than a consensus exists as to whether chronic treatment with selegiline in combination with levodopa/carbidopa in patients with Parkinson's disease, is associated with more pronounced orthostatic hypotension than treatment with levodopa/carbidopa alone. To resolve this issue, we compared orthostatic tolerance and autonomic reflexes in 95 patients with Parkinson's disease treated chronically with either selegiline alone (n = 10), levodopa/carbidopa alone (n = 49) or both agents combined (n = 36). Supine heart rate and blood pressure, autonomic cardiovascular reflexes and the frequency and magnitude of orthostatic hypotension were similar in all three treatment groups.
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