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  • Title: [Role of placental apoptosis in fetal growth restriction].
    Author: Liu Y, Gao P, Xie Y, Wang S, Dai M, Jiang S.
    Journal: Zhonghua Fu Chan Ke Za Zhi; 2002 Dec; 37(12):721-2. PubMed ID: 12622913.
    Abstract:
    OBJECTIVE: To determine the relationship of placental cellular apoptosis and pathophysiology of fetal growth restriction (FGR). METHODS: Placental samples were obtained from 18 pregnancies complicated by FGR and 14 normal pregnancies. Terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end labeling (TUNEL) and transmission electron microscopy were used to confirm the occurrence of apoptosis. RESULTS: In FGR group the placental apoptosis rate was (n = 18) 12.1 per thousand, the average placental weight was (236 +/- 24) g, the average birth weight was (2,071 +/- 428) g; In normal group (n = 14), the placental apoptosis rate was 7.3 per thousand, the average placental weight was (354 +/- 63) g, the average birth weight was (3,411 +/- 588) g (P < 0.05). The incidence of apoptosis was significantly higher in placental samples from pregnancies with FGR compared with normal placental samples (P < 0.05). Under transmission election microscopy, apoptosis was obviously compact and the chromatins were formed as mass. CONCLUSION: These results suggest that apoptosis may play a role in the pathophysiologic mechanisms of FGR.
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