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  • Title: Chloral hydrate causes breakdown of polysomes in Chlamydomonas reinhardi in vivo.
    Author: Cross J, McMahon D.
    Journal: J Biol Chem; 1976 May 10; 251(9):2637-43. PubMed ID: 1262338.
    Abstract:
    Chloral hydrate produces a biphasic change in the proportion in the cell. Within 1 to 2 min after addition to cells, it inhibits protein synthesis and causes polysomes to break down. The ribosomes dissociate from mRNA by a process which requires protein synthesis but which is apparently abnormal. Released ribosomes do not appear to be bound to fragments of mRNA, but do carry a nascent polypeptide chain. Protein synthesis remains inhibited by more than 85% for over 24 hours, but the apparently normal polyteraction of the cells with chloral hydrate itself and not from its conversion of its usual metabolic products, trichloroethanol or trichloroacetic acid.
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