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  • Title: An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women.
    Author: Mutlu-Türkoğlu U, Oztezcan S, Telci A, Orhan Y, Aykaç-Toker G, Sivas A, Uysal M.
    Journal: Clin Exp Med; 2003 Feb; 2(4):171-4. PubMed ID: 12624707.
    Abstract:
    Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoproteincholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoproteincholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.
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