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  • Title: Effect of D-amino acids on some mitochondrial functions in rat liver.
    Author: González-Hernández JC, Aguilera-Aguirre L, Pérez-Vázquez V, Ramírez J, Clemente-Guerrero M, Cortés-Rojo C, Saavedra-Molina A.
    Journal: Amino Acids; 2003; 24(1-2):163-9. PubMed ID: 12624749.
    Abstract:
    We studied the role of the D-amino acids (D-aa) D-serine, D-alanine, D-methionine, D-aspartate, D-tyrosine and D-arginine on rat liver mitochondria. The stability of D-amino acids, mitochondrial swelling, transmembrane potential and oxygen consumption were studied under oxidative stress conditions in rat liver mitochondria. In the presence of glutamate-malate all D-aas salts increased mitochondrial swelling, while in the presence of succinate plus rotenone only D-ala, D-arg and D-ser, induced mitochondrial swelling. The transmembrane potential (deltapsi) was decreased in the presence of 1 microM Ca(2+). The D-aas inhibited oxygen consumption in state 3. The D-aa studied exerted effects on mitochondria via an increase of free radicals production.
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