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  • Title: [Clinical study of amoxicillin used in the otorhinolaryngological field (author's transl)].
    Author: Okamoto K, Yoshida A, Kona A, Ikeda M, Muraoka J.
    Journal: Jpn J Antibiot; 1976 Jan; 29(1):22-6. PubMed ID: 1263338.
    Abstract:
    The following results were obtained from oral administration of amoxicillin to 20 cases of acute otorhinolaryngological infections for 5 consecutive days; the daily dose was 1,500 mg for adult and 750mg for child. 1. Six cases with acute tonsillitis, 6 with acute pharyngolaryngitis, 5 with acute otitis media, 2 with furuncle of the nose and 1 with acute laryngitis were treated with amoxicillin. This drug was remarkably effective in 2 of 20 cases in total, effective in 15, slightly effective in 1 and non-effective in 2. 2. The sensitivity test to amoxicillin by the use of ampicillin sensitivity disk revealed that all of isolated bacteria were remarkably sensitive to amoxicillin, except one strain of Staphylococcus aureus which was moderately sensitive. 3. Side effect occurred at the rate of 25%; 4 cases of eruption and 1 of esophagitis. Other severe side effects were not observed. From the above results, amoxicillin is considered to be an effective drug for clinical application in the otorhinolaryngological field.
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