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  • Title: Involvement of caveolin-2 in caveolar biogenesis in MDCK cells.
    Author: Lahtinen U, Honsho M, Parton RG, Simons K, Verkade P.
    Journal: FEBS Lett; 2003 Mar 13; 538(1-3):85-8. PubMed ID: 12633858.
    Abstract:
    Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin-2 and disappearance of caveolae from the basolateral membrane. Correspondingly, in MDCK cells over-expressing caveolin-2 the basolateral membrane exhibited an increased number of caveolae. These results indicate the involvement of caveolin-2 in caveolar biogenesis.
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