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  • Title: Simulated microgravity conditions affect poly(ADP-ribose) polymerase activity in cultured human lymphocytes.
    Author: Cesarone CF, Camboni MG, Meloni MA, Cogoli A, Pippia P.
    Journal: J Gravit Physiol; 2001 Jul; 8(1):P23-4. PubMed ID: 12638608.
    Abstract:
    Human peripheral blood lymphocytes (PBL), activated with concanavalin A (ConA), were used to determine the effects of simulated microgravity on poly(ADP-ribose) polymerase (PARP) activity. Results indicate that the ConA stimulation of human cultured PBL induces a partial but signitficant inhibition of PARP-1 acitvity (-30%). In control PBL, not exposed to ConA, after 24 hours, there was a clear decrease in PARP-1 acitivty (-40%). In PBL exposed to ConA and simulated weightlessness, activity decreased by -37%.
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