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  • Title: Bioactive kaurane diterpenes and coumarins from Fortunella margarita.
    Author: el-Shafae AM, Ibrahim MA.
    Journal: Pharmazie; 2003 Feb; 58(2):143-7. PubMed ID: 12641334.
    Abstract:
    Two bioactive pyranocoumarins 1 (sesselin) and 3 (xanthyletin) and one prenylated coumarin 2 (suberosin), beside three rare kaurene diterpenes 5-7 were isolated from the roots of Fortunella margarita. Their structures were determined from their spectroscopic data, including 1H/13C 2D NMR experiments. The kaurene diterpenes 5-7 are reported in Rutaceae for the first time. Diterpene 5 was found to be a potent stimulator of uterine contraction; it also caused stimulation of brain activity.
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