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  • Title: Genomic transcriptional activity and the structure of chromatin.
    Author: Reeves R, Jones A.
    Journal: Nature; 1976 Apr 08; 260(5551):495-500. PubMed ID: 1264202.
    Abstract:
    Nucleic acid hybridisation has shown that micrococcal nuclease-derived chromatin subunits from the cells of Xenopus laevis contain fragments of ribosomal 28S, 18S and 5S RNAS within the population of 200 base-pair pieces of DNA. Subunits from cultured embryonic cells actively transcribing ribosomal RNA contain only 70-74% of the cistrons present in undigested wild-type DNA, while subunits from adult erythrocytes not active in RNA transcription contain close to 90% of the ribosomal cistrons in native chromatin.
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