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  • Title: [Granulopoiesis: comparison of several methods for studying production and bone marrow cellularity (author's transl)].
    Author: Dresch C, Faille A, Rain JD, Najean Y.
    Journal: Nouv Rev Fr Hematol; 1975; 15(1):31-55. PubMed ID: 126423.
    Abstract:
    Several methods measuring the granulocyte production have been compared in normal subjects, hypoplastic granulopenia, chronic leucopenia and acute leukemia: the granulocyte turnover-rate after injection of in vitro 51Cr labelled autologous granulocytes, the efficiency of 75Se-selenothionine in vivo labelling, the flow-out of the myelocyte compartment after in vitro flash-labelling with 3H-thymidine. The two first methods are correlated and measure the global effective production of granulocytes. The third method is a fractional measure of the bone marrow production and is not correlated with the former ones. The ratio between the granulocyte turnover-rate and the flow-out of the bone marrow proliferative pool is a measure of the bone marrow cellularity. Discrepancies between this measure and the granulocyte turnover-rate has been found only in leukaemic patients.
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