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  • Title: Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones as potent and selective I(Ks)-blocking class III antiarrhythmic agents.
    Author: Butcher JW, Liverton NJ, Claremon DA, Freidinger RM, Jurkiewicz NK, Lynch JJ, Salata JJ, Wang J, Dieckhaus CM, Slaughter DE, Vyas K.
    Journal: Bioorg Med Chem Lett; 2003 Mar 24; 13(6):1165-8. PubMed ID: 12643935.
    Abstract:
    Novel 5-cyclopropyl-1,4-benzodiazepin-2-ones having various N-l substituents were identified as potent and selective blockers of the slowly activating cardiac delayed rectifier potassium current (I(Ks)). Compound 11 is the most potent I(Ks) channel blocker reported to date.
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