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  • Title: Mechanical ventricular support lowers pulmonary vascular resistance in a patient with congential heart disease.
    Author: Petrofski JA, Hoopes CW, Bashore TM, Russell SD, Milano CA.
    Journal: Ann Thorac Surg; 2003 Mar; 75(3):1005-7. PubMed ID: 12645735.
    Abstract:
    Severely elevated pulmonary vascular resistance (PVR) is a relative contraindication to orthotopic heart transplantation. A potential novel strategy to reverse elevated PVR may be implantation of a chronic left ventricular assist device with subsequent left ventricular unloading. We present a patient with elevated PVR secondary to congenital heart disease who was listed for heart-lung transplant. The patient underwent placement of biventricular assist devices and subsequently experienced marked reduction of PVR, ultimately enabling successful heart transplantation.
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