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  • Title: Phospholipid scramblase 3 is the mitochondrial target of protein kinase C delta-induced apoptosis.
    Author: Liu J, Chen J, Dai Q, Lee RM.
    Journal: Cancer Res; 2003 Mar 15; 63(6):1153-6. PubMed ID: 12649167.
    Abstract:
    Protein kinase C (PKC) delta translocates to mitochondria during apo-ptosis,but its mitochondrial target remains unclear. We found that PKC-delta physically interacted with and phosphorylated phospholipid scramblase 3 (PLS3) after UV irradiation. PLS3 is a high-affinity substrate for PKC-delta in vitro with the K(m) at 10.5 nM. Cells expressing wild-type PLS3 became apoptotic on phorbol ester stimulation, whereas the control cells did not. Expression of a mitochondrial-targeted PKC-delta enhanced apoptosis more prominently in HeLa-PLS3 cells than control HeLa cells and HeLa cells expressing an inactive PLS3 mutant. These results indicate that PLS3 is a downstream effector of PKC-delta in the mitochondria.
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