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  • Title: Low incidence of community-acquired pneumonia among human immunodeficiency virus-infected patients after interruption of Pneumocystis carinii pneumonia prophylaxis.
    Author: Eigenmann C, Flepp M, Bernasconi E, Schiffer V, Telenti A, Bucher H, Wagels T, Egger M, Furrer H, Swiss HIV Cohort Study.
    Journal: Clin Infect Dis; 2003 Apr 01; 36(7):917-21. PubMed ID: 12652393.
    Abstract:
    We compared the incidence of bacterial pneumonia among 336 patients who discontinued trimethoprim-sulfamethoxazole (TMP-SMX) as prophylaxis against Pneumocystis carinii pneumonia (PCP) with that among 75 patients who fulfilled the criteria for discontinuation but continued receiving prophylaxis. The difference in the overall incidence rates for the 2 groups (1.2 events per 100 person-years) was not statistically significant. Discontinuation of TMP-SMX prophylaxis against PCP is not associated with a significant increase in the incidence of bacterial pneumonia among patients with a sustained CD4 cell count increase to >200 cells/microL.
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