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  • Title: Angiosarcoma masquerading as embryonal carcinoma in the metastasis from a mature testicular teratoma.
    Author: Sahoo S, Ryan CW, Recant WM, Yang XJ.
    Journal: Arch Pathol Lab Med; 2003 Mar; 127(3):360-3. PubMed ID: 12653585.
    Abstract:
    Sarcoma can arise within a germ cell tumor (GCT) from a malignant transformation of teratomatous elements or as late sequelae to radiation therapy. Angiosarcoma as a malignant component in testicular GCTs has rarely been reported and is often misdiagnosed as embryonal carcinoma. We report the case of a 23-year-old man with mature teratoma of the testis and retroperitoneal metastasis exhibiting components of mature teratoma intermingled with high-grade angiosarcoma. It is important to recognize the presence of a high-grade sarcomatous component within a GCT because of its aggressive clinical behavior and different response to therapy.
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