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  • Title: Substitution of a non-retinal phospholipase C in Drosophila phototransduction.
    Author: Kim S, Chen DM, Zavarella K, Fourtner CF, Stark WS, Shortridge RD.
    Journal: Insect Mol Biol; 2003 Apr; 12(2):147-53. PubMed ID: 12653936.
    Abstract:
    The Drosophila norpA gene encodes at least two subtypes of phospholipase C (PLC), one of which is essential for phototransduction and the other is utilized in signalling pathways other than phototransduction. The two subtypes of norpA-PLC differ by 14 amino acids that have been proposed as important for the function of PLC in different signalling pathways. The present study aimed to determine whether norpA subtype II enzyme can functionally substitute for the subtype I enzyme in the phototransduction pathway. We found that the non-retinal norpA-PLC enzyme can substitute for its retinal counterpart, but that there is a reduced rate of repolarization of photoreceptors following intense light stimuli. This reduced repolarization might be due to the inability of a regulatory component being able to interact with the non-retinal norpA-PLC enzyme.
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