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  • Title: Efficacy of micafungin alone or in combination against systemic murine aspergillosis.
    Author: Luque JC, Clemons KV, Stevens DA.
    Journal: Antimicrob Agents Chemother; 2003 Apr; 47(4):1452-5. PubMed ID: 12654692.
    Abstract:
    We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.
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