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  • Title: Cellular and humoral local immune responses in sheep experimentally infected with Oestrus ovis (Diptera: Oestridae).
    Author: Tabouret G, Lacroux C, Andreoletti O, Bergeaud JP, Hailu-Tolosa Y, Hoste H, Prevot F, Grisez C, Dorchies P, Jacquiet P.
    Journal: Vet Res; 2003; 34(2):231-41. PubMed ID: 12657215.
    Abstract:
    Cellular and humoral local responses were investigated following repetitive artificial Oestrus ovis infections in lambs. The presence of larvae induced a huge local recruitment of either leucocytes (T and B lymphocytes, macrophages) or granulocytes (eosinophils, mast cells and globule leucocytes). This cellular response was more pronounced in the ethmoid and sinus (development sites of second and third instar larvae) than in the septum or turbinates where first instar larvae migrate. Infected lambs produced Oestrus ovis specific IgG and IgA antibodies in their mucus. This local humoral response was mainly directed against larval salivary gland antigens and not against larval digestive tract antigens. Compared to the control animals, the sinusal mucosa of infected animals was extremely thickened and the epithelium exhibited hyperplasia, metaplasia and eosinophilic exocytosis. The possible roles of these local immune responses in the regulation of O. ovis larvae populations in sheep are discussed.
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