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  • Title: Over-production of porphyrins and heme in heterotrophic bacteria.
    Author: Philipp-Dormston WK, Doss M.
    Journal: Z Naturforsch C Biosci; 1975; 30(3):425-6. PubMed ID: 126586.
    Abstract:
    In Escherichia coli, Pseudomonas aeruginosa, and Achromobacter metalcaligenes gamma-aminolevulinic acid synthase and gamma-aminolevulinic acid dehydratase appear to be the rate limiting enzymes of porphyrin and heme biosynthesis. Bypassing of these enzymes by addition of gamma-aminolevulinic acid or porphobilinogen results in overproduction of tetrapyrroles.
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